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Biosafety Cabinet Selection Guide

2026-01-14

Do You Need Integration with Ventilation and Cleanroom Engineering?

In laboratory construction, biosafety cabinet (BSC) selection is not a standalone equipment decision. It directly affects ventilation design, cleanroom performance, project cost, and long-term operational safety.
An incorrect selection can result in mismatched airflow, failure to achieve required cleanliness levels, or even costly redesign and reconstruction.

This guide explains when and how biosafety cabinets must be integrated with ventilation systems and cleanroom engineering, helping you avoid common pitfalls and make informed decisions.

1. Why Integration Matters

Biosafety cabinets are classified by exhaust configuration, and each type places very different demands on the ventilation system:

Class I
Draws room air into the cabinet and exhausts it through HEPA filtration, either back to the room or outdoors.
Class II
Recirculates approximately 70% of air through HEPA filters; 30% is exhausted.
Class III
Fully enclosed, gas-tight cabinets with 100% HEPA-filtered supply and exhaust air.

Selecting the wrong cabinet type can lead to:

Ventilation system overload
Unstable room pressure
Compromised containment and operator safety

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